It’s an understatement to say that Seattle rap duo Macklemore & Ryan Lewis have had a rocket ride to stardom. The independent duo, who were playing clubs last year and were barely a blip on the national radar, has gone from underground favorites to Billboard chart champions and, now, arena headliners in the span of less than a year.

The pair will kick off their first arena run on Oct. 22, setting up in some of the biggest venues of their career after returning from a string of...

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